Maitake Gold 404 Mushroom Extract
MaitakeGold 404 is a potent Maitake mushroom extract developed by Dr. Hiroaki Nanba, PhD., the inventor of Maitake nutraceuticals. MaitakeGold represents such a significant improvement in Maitake formulations that it was granted a U.S. Patent (U.S. Patent # 5,854,404), and is the only Maitake supplement that carries Dr. Nanba’s personal endorsement.
Maitake is the only medicinal mushroom that can be hot water extracted and sold in a liquid form and still provide an effective dose for immune support. MaitakeGold 404 is a hot water extract preserved in glycerin, offering an alcohol free supplement for immune support.
The other liquid mushroom supplements on the market are preserved in alcohol and are called tinctures, also known as “cold water extracts”.
These products contain very low levels of active compounds, including the key immuno-modulating compounds, the polysaccharides, that define a mushroom as medicinal. This is because tinctures are processed at room temperature, far below the temperatures required for hot water extraction. Tincturing works for plants but not mushrooms or mushroom mycelium.
Medicinal mushrooms are prepared as hot water extracts in 100% of the herbal and scientific references for a reason, it is the only preparation method capable of releasing the active compounds from the indigestible cell walls of mushrooms and mushroom mycelium and into a bioavailable form.
As part of a multi-year research collaboration, researchers at Memorial Sloan-Kettering Research Hospital conducted a Phase I/II clinical trial. Thirty four subjects took MaitakeGold 404® at varying doses for three weeks. Researchers discovered that balanced immune support (immunomodulation) occurred in subjects at all dosage levels (including low doses), with no adverse effects or toxicity.* After three weeks, T cell activity increased, as did levels of immune-enhancing cytokines (IL-2, TNF-ά, IFN-γ). This study demonstrated that MaitakeGold 404® supports a healthy immune response.
Maitake Gold 404 Benefits
Clinical research on Maitake fractions has focused primarily on immuno-modulating properties. Although no controlled human clinical studies have yet to be completed, studies involving the use of MaitakeGold 404 for immune support are in progress at Sloan-Kettering. The results of the in vitro research and uncontrolled human clinical research suggest significant immuno-modulating properties including activation of Natural Killer cells.
Maitake Gold 404 contains one of the most powerful beta glucans for aiding and improving the immune system. While other forms of beta glucans exist, such as oat, barley, and baker’s yeast, the Maitake fractions have a unique branching pattern that gives them superior immunological activity and makes them more easily absorbed by the body. This unique branching pattern is also the reason that hot water extracts of Maitake mushroom can be concentrated to the point where they can be sold in liquid form.